| THE ASSOCIATION OF THE HIF1A C1772T GENETIC POLYMORPHISM WITH BREAST CANCER IN EGYPTIAN POPULATION |
| Paper ID : 1013-YRC2022 |
| Authors |
|
Amani A Abdelgalil * Suez Canal Unicersity |
| Abstract |
| Polymorphisms in the hypoxia-inducible factor 1 (HIF-1) gene have been studied for their potential role in modulating genetic predisposition to cancer. The goal of this study was to see if the HIF1A C1772T gene polymorphism was linked to an increased risk of breast cancer in Egyptian women. This study enrolled a total of 286 participants, including 132 healthy controls and 154 breast cancer patients. The polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method was used to determine genotypes. No C/C genotype was observed in patients and controls and the frequencies of CT and TT genotype of C1772T polymorphism were 35.1% vs. 27.3 %, and 64.9 vs. 72.7% in breast cancer patients and control individuals respectively. Between patients and controls, there was no significant difference in genotype and allele frequencies of the HIF-1C1772T polymorphism (p>0.05). These findings demonstrate that the HIF-1 polymorphism (C1772T) is not linked to the incidence of breast cancer in Egyptian women. |
| Keywords |
| HIF-1a, polymorphism, Breast cancer, Egyptian population. |
| Status: Accepted (Poster Presentation) |
