| NEW TERBIUM COMPLEX FOR DETECTION OF GEMIFLOXACIN IN PHARMACEUTICAL FORMULATIONS |
| Paper ID : 1021-YRC2022 |
| Authors |
|
Rania M. Goda *1, Zeinab Mohamed Anwar1, Axel Duerkop2, Gasser Mohamed Khairy1 1suez canal university 2University of Regensburg |
| Abstract |
| A new spectrofluorimetric approach has been developed for the measurement of Gemifloxacin Mesylate (GMF), a broad-spectrum fluoroquinolone anti-bacterial in its pure form and pharmaceutical drug. The interaction of Gemifloxacin Mesylate with the Tb (III)- 3-allyl-2-hydroxybenzohydrazide (AHB) complex is based on the enhancement of the fluorescence. Under optimal conditions, this reaction product was measured spectrofluorimetric at 545 nm after excitation at 308 nm. The calibration graph had a linear relationship with a best correlation coefficient of 0.995, a limit of quantification (LOQ) of 4.67 µg/mL, and a detection limit (LOD) of 1.54 µg/mL for the range of 0–10 µg/mL. The thermodynamic characteristics of Gemifloxacin mesylate in the presence of Tb (III)-AHB were evaluated. The binding reaction ∆H and ∆S were found to be 25.13 kJ/mol and 165.54 J/mol/K, respectively. The proposed approach is supposed to be the most practical analytical technical method for determining pure forms of the drug and pharmaceutical preparations, as well as for quality control. |
| Keywords |
| Gemifloxacin mesylate, spectrofluorimetric, Terbium complex |
| Status: Conditional Accept (Poster) |
