| PREVALENCE OF SCC-MECA, ERMB, AND FUSIDIC ACID-RESISTANT GENES IN STAPHYLOCOCCAL SPECIES RECOVERED FROM ACNE VULGARIS IN EYGPT |
| Paper ID : 1053-YRC2022 |
| Authors |
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Noha Mahmoud Hashem *1, Alaa El din Mahmoud Hosny2, Ali A Abdelrahman3, Samira Zakeer4 1Suez canal 2Cairo University 3Suez Canal university 4Suez Canal |
| Abstract |
| 1- INTRODUCTION: Acne vulgaris is a common disorder involving the pilosebaceous unit. Acne frequently endures into adulthood, with 26% of women and 12% of men reporting acne in their 40s. Acne vulgaris patients are usually subjected to topical antibiotic treatment including erythromycin and fusidic acid as the first line of treatments, which have been associated with the development of resistance. A multidrug-resistant Staphylococcal species including methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis are colonizing patients with acne Vulgaris. The infections caused by MRSA are challenging clinical treatment. MRSA is the most common nosoco‌mial pathogen that causes infections, ranging from mild skin infections to severe and fatal necrotizing pneumonia [5]. 2- OBJECTIVES: In this study, we attempt to investigate the dissemination of resistance determinants, among staphylococcal species colonizing Acne Vulgaris patients, related to fusidic acid antibiotics mainly the horizontally transmitted fusB and fusC genes, Moreover determine the occurrence of ermB gene related to erythromycin resistance as well the prevalence of the mecA gene linked to B-lactam resistance. 3- METHODS: using the polymerase chain reaction technique 4- RESULTS & DISCUSSION: the dissemination of the mecA gene was most common followed by the horizontally transferred fusidic acid-resistant determinant fusB that was dominant among S.epidermidis. Afterward, the horizontally transferred fusidic acid-resistant determinant fusC gene was dominant as well among the S.aureus isolates. Concerning the distribution of ermB gene, it was infrequent in this study. |
| Keywords |
| Acne vulgaris, Fusidic acid, Staphyloccocus aureus, Staphyloccocus epidermidis |
| Status: Accepted (Poster Presentation) |
