| LIPOPOLYSACCHARIDE FROM RHODOBACTER SPHAEROIDES PROTECTS AGAINST ETHANOL–INDUCED KIDNEY TOXICITY IN EXPERIMENTAL RATS |
| Paper ID : 1087-YRC2022 (R1) |
| Authors |
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Eman Taha Mehanna *1, Al-Shimaa A. Ali2, Fatma El-shaarawy3, Noha M. Mesbah2, Dina M. Abo-elmatty2, Nora M. Aborehab4 1Suez Canal Unibersity 2Suez Canal University 3Sinai University 4October University for Modern Science and arts (MSA) |
| Abstract |
| This study aimed to investigate the protective effects of the toll-like receptor 4 (TLR4) antagonist lipopolysaccharide from Rhodobacter sphaeroides (LPS-RS) against ethanol-induced nephrotoxicity in experimental rats. The study involved a normal control group, LPS-RS group, two groups were given ethanol (3 and 5 g/kg/day) for 28 days, and two other groups (LPS-RS + 3 g/kg ethanol) and (LPS-RS + 5 g/kg ethanol) received a daily dose of LPS-RS (800 μg/kg) before ethanol. Administration of ethanol caused significant increase in the serum levels of urea and creatinine and the expression of nuclear factor kappa B (NF-κB) and the levels of tumor necrosis factor-alpha (TNF-α) in the kidney tissue. Ethanol also significantly increased the levels of kidney injury molecule-1 (KIM-1), vascular non-inflammatory molecule-1 (vanin-1) and cytochrome C (Cyt C) in the kidney tissue; whereas LPS-RS + ethanol groups had significantly lower levels of those parameters. In conclusion; this study reports anti-inflammatory and protective effects of the TLR4 antagonist LPS-RS against ethanol induced toxicity in the kidney of experimental rats. |
| Keywords |
| kidney injury molecule-1, lipopolysaccharide from Rhodobacter sphaeroides, nuclear factor kappa B, toll-like receptor 4. |
| Status: Accepted (Oral Presentation) |
