| PREPARATION AND CHARACTERIZATION OF SOME CHEMICALLY MODIFIED CHITOSAN NANOPARTICLES DERIVATIVES AS DRUG CARRIER |
| Paper ID : 1088-YRC2022 |
| Authors |
|
Abdelhakim Salama Sharban * Suez Canal University |
| Abstract |
| Chitosan joined the pharmaceuticals field in the early 1990s, piqueing the interest of researchers and industry to develop more effective and new therapeutic systems based on it. The versatility of chitosan stems from its active amino groups, which operate as an active site for a range of novel group attachments under mild reaction conditions, as well as the cationic nature of the chitosan, which is also related to the amino groups and so known as amino polysaccharide. N-acetyl-D-glucosamine and D-glucosamine units with one amino (NH2) group and two hydroxyl (OH) groups in each repeating glycosidic unit make up the structure (Fig. 1). Dealing with chitosan by making a chemical modification is an essential and exciting topic nowadays, this due to the wide application of chitosan in different scientific fields. Chemical modification is an effective way to improve the solubility of chitosan. At the same time, it could also improve the physicochemical properties of chitosan such as thermal stability, rheological properties, oxidation resistance, and antibacterial properties. Hence, the application of chitosan is broadened in various fields |
| Keywords |
| Chitosan, Drug Delivery, Chemical Modification, Nanoparticle. Copolymer |
| Status: Accepted (Oral Presentation) |
