| INHIBITION OF SKIN CANCER GROWTH VIA METFORMIN LOADED ETHOSOMES |
| Paper ID : 1092-YRC2022 (R1) |
| Authors |
|
Ibrahim A. Mousa * Suez Canal University |
| Abstract |
| Penetration of the drug into the deepest skin layers is counted to be an important scientific interest. By using a new formulation that depended on ethosomes as metformin hydrochloride carriers were designed and evaluated by measuring their efficacy in penetration of the stratum corneum and sustained release into the skin. The ethosomes can penetrate into the deepest layers of the skin due to the effect of both ethanol and iso-propyl alcohol and can retain on the skin due to stearylamine. A statistical Box- Behnken experimental design was developed by using three variables at three levels; lecithin concentration, cholesterol concentration, and mix of ethanol and isopropyl alcohol concentrations. In vivo antitumor activity of metformin-loaded ethosomal gel on skin cancer was greater than antitumor activity compared to the gel containing free metformin. Finally, Lower lecithin, high ethanol, isopropyl alcohol, and moderate cholesterol improved permeation rate while stearylamine addition caused an increase in metformin retention within the skin layers. It can be concluded that metformin-loaded ethosomes are a promising remedy for treating skin cancer. |
| Keywords |
| skin cancer, Entrapment efficacy, Ethosomes, metformin, In vitro permeation, Zeta potential |
| Status: Accepted (Oral Presentation) |
