| MAGNETIC RESONANCE IMAGING CORRELATION WITH IMMUNOHISTOCHEMICAL AND EPIGENETIC MARKERS IN ASSESSMENT OF BREAST CANCER |
| Paper ID : 1101-YRC2022 (R1) |
| Authors |
|
Aya Shahat El-Rawy * Suez canal university |
| Abstract |
| Introduction: Breast cancer is a heterogeneous disease with a wide range of clinical behavior, histologic subtypes, therapeutic options, and outcomes. The different biology and histology of breast cancer display different tumor morphology at breast magnetic resonance imaging. The study aimed to evaluate the correlation between MRI morphological and kinetic features, immunohistochemical and epigenetic (linc-ITGB1) markers in breast cancer cases. Subjects and Methods: A total of 115 women (80 cases and 35 controls) with BIRAD 4 Category breast lesions were included. Results: The shape (p=0.009), size of the lesion (p=0.003) and pattern of enhancement (p=<0.001) were significantly correlated with the molecular markers. Luminal subtypes are more likely to be presented with irregular shaped and non- circumscribed margin masses (97% for luminal A and 94.1% for luminal B). Triple negative cancers are frequently presented with regular masses, circumscribed margins and peripheral rim enhancement (50% of TN tumors). Although the ITGB1 was overexpressed by 4.9 folds in breast cancer cases compared to benign controls, we could not find a significant correlation of this gene expression and the MRI features or molecular subtypes (p=0.948). Conclusion: MRI features can be a reliable predictor of breast cancer molecular subtypes. Although the ITGB1 was overexpressed in our breast cancer cases we could not prove a significant correlation between this gene and MRI features or molecular subtypes of the lesions. |
| Keywords |
| Breast Cancer, MRI, Molecular Subtypes, epigenetic marker. |
| Status: Accepted (Oral Presentation) |
